|
KMID : 0350519930460020729
|
|
Journal of Catholic Medical College
1993 Volume.46 No. 2 p.729 ~ p.737
|
|
|
The Influence of Insulin and Glucose Concentration on Regeneration of The Injured Caudal Nerve by Compression in Rat
|
|
|
|
|
Abstract
|
|
|
The influence of insulin and glucose concentration on electrophysiologic recoveryof experimental compressionneuropathy of the caudal nerve was studied in 80 adult Sprague-Dawley albino rats, which were divided equally into four groups. control
group was
used as normal rats with compression of the caudal nerve, Glucose injected group was used as rats ofcaudal nerve compression with glucose injection(2.5gm/kg, twice/day). Hyperglycemic group was induced by injection of streptozotocin of 50mg/kg
before
caudal nerve compression of rats. Insulin-hyperglycemic group was induced by injection ofstreptozotocin before caudal nerve compression of rats, and insulin treat-ment(0.5U/day).
The rat´s tail was compressed with the pressure of approximately 10kg/㎠ for 5 minutes for all groups.
In each experimental group, the plasma insulin and glucose concentration, and the plasma insulin(μU/ml)/glucose(mg/dl) concentration ratio(insulinogenic index), and the nerve conduction velocity, and the amplitude and latencyof compound muscle
action
pctentials were measured before and weekly after nerve compression, respectively.
The objective of this experiment was to investigate the influence of plasma insulin and glucose concentration on regeneration of injured nerve.
@ES The results were as follows:
@EN 1. After caudal nerve injury by compression, the recovery of nerve conduction velocity and latency of compound muscle action potentials required 3 weeks and 4 weeks in control gorup, and 2 weeks and 3 weeks in glucose injected group, and 5
weeks and
5 weeks in hyperglycemic group, and 3 weeks and 4 weeks in insslin-hyperglycemic group, respectively.
2. After caudal nerve injury by compression, the recovery of amplitude of compound muscle action potentials required 4 weeks in control group and 3 weeks in glucose injected group, but there was no recovery until 5 weeks after caudal nerve
compression
in hyperglycemic and insulinhyperglycomic groups.
3. Plasma insulin/glucose concetration ratio were 0.24 in glucose injected group, 0.20 in control group, 0.12 in insulin-hyperglycemic group and0.02 in hyperglycemic group.
The results suggest that both the increased plasma insulin and glucose concentration were related to the nerve regeneration, but the interaction between plasma insulin and glucose plays an important role rather than excessive plasma glucose
during
regeneration of the perigheral nerve.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|